How OPTI-FREE® RepleniSH® MPDS Measures Up

1. Maintain the tear film on the contact lens surface

The right MPS can help maintain the tear film on the contact lens surface. This is assessed by evaluating lens surface wettability.^1,2 (The lower the wetting angle, the more moisture retained on the lens surface.)

OPTI-FREE® RepleniSH® MPDS
at 14 hours

ReNu MultiPlus* MPS
at 8 hours

OPTI-FREE® RepleniSH® retains a natural tear film on the lens surface for 14 hours^1-3

2. Minimize corneal epithelial disruption

The outer epithelium can be disrupted by certain lens / solution combinations.^4,5 Corneal staining reveals disruption. Corneal staining has been associated with a higher incidence of infiltrative ocular events.⁶

OPTI-FREE® RepleniSH® MPDS and PureVision,* an example of minimal corneal staining

ReNu MultiPlus* MPS and PureVision*, an example of excessive corneal staining

OPTI-FREE® RepleniSH® MPDS exhibits minimal corneal staining with all lens/solution combinations tested^7,8

3. Minimize insult to the basal lamina

The basal lamina is the cornea's basement membrane. Compromising this layer allows penetration into the stroma.⁴ Penetration into the stroma indicates that all layers of the epithelium have been breached. Fluorescein permeability is used to evaluate epithelial integrity.^4,5

1. Data on file, Alcon Laboratories.
2. Schachet J, Zigler L, et al. Clinical assessment of a new multi-purpose disinfecting solution in asymptomatic and symptomatic patients. Poster presented at: AAO; December 2006; Denver, CO.
3. Meadows D, Ketelson H, Napier L, Christensen M, Mathis J. Clinical ex vivo wettability of traditional and silicone hydrogel soft contact lenses. Poster presented at BCLA; May 2006; Birmingham, UK.
4. Hall JQ, Paugh JR, Peinovich MC, Ramsey AC, Meadows D. A pilot study of the effect of silicone-hydrogel lenses and marketed multipurpose solutions on human epithelial barrier function. Invest Ophthalmol Vis Sci. 2007; 48: ARVO E-Abstract 5400.
5. Paugh JR, Webb JR, Ramsey AC, Meadows D, Napier L. Clinical and epithelial barrier evidence of lens material and multipurpose solution bio-incompatibilities. Poster presented at BCLA; May 2008; Birmingham, UK.
6. Carnt N, Jalbert l, Stretton S, Naduvilath T, Papas E. Solution toxicity in soft contact lens daily wear is associated with corneal inflammation. Optom Vis Sci. 2007; 84:309-315.
7. Andrasko GJ, Ryen KA, Garofalo RJ, Lemp JM. Compatibility of silicone hydrogel lenses with multi-purpose solutions. Invest Ophthalmol Vis Sci. 2006; 47:ARVO E-Abstract 2392.
8. Data referenced from Contact Lens Research Services at StainingGrid.com. Accessed April 3, 2008.
9. Fleiszig S. The pathogenesis of contact lens-related keratitis. Optom Vis Sci. 2006; 83:866-873.