Can corneal staining be related to differences between POLYQUAD® and the PHMB-preserved systems?

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Several studies show statistically significant increased corneal staining and tarsal plate changes with multi-purpose solution containing PHMB. The parameters were evaluated with various lens materials including Group II, Group IV, and silicone hydrogel contact lenses, after various wearing time intervals.^1-6

How can a lens care solution impact the corneal staining with silicone hydrogel lenses?

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OPTI-FREE® RepleniSH® MPDS containing POLYQUAD® preservative has received FDA clearance for use with silicone hydrogel lenses in addition to traditional soft lens materials.

According to investigators in a clinical study, "...there is potential for certain biguanide-containing MPS systems to invoke significant corneal staining. Switching to non-PHMB based regimens will eliminate this complication in most instances.¹

Users of OPTI-FREE® RepleniSH® are likely to show significantly less corneal staining compared to users of a biguanide-based care solution.^7-8

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Are multi-purpose lens care solutions an overlooked risk factor for tarsal abnormalities?

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The tarsal conjunctiva is very sensitive to lens care solutions. Tarsal reactions occur frequently and the severity can be influenced by the solution. Solutions containing biguanides resulted in higher tarsal plate scores with Group IV lenses than were observed for multi-purpose disinfecting solutions containing POLYQUAD® preservative.⁶

Does your recommendation of lens care solution impact patient comfort, patient retention and ultimately the success of your practice?

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OPTI-FREE® RepleniSH® MPDS increased comfort over time for wearers of the most common soft contact lens material who experience discomfort.⁷ Silicone hydrogel patients who were using OPTI-FREE® RepleniSH® with TearGlyde® reconditioning system reported significantly less use of rewetting drops than did patients using Complete* MoisturePLUS*.⁸

Of all of the potential causes of dropout, comfort issues stand out as the most difficult to diagnose, troubleshoot and eliminate.

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What is the benefit of POLYQUAD® in OPTI-FREE® RepleniSH®?

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OPTI-FREE® RepleniSH® MPDS with POLYQUAD® preservative is formulated to minimize preservative uptake and release. This helps to ensure that OPTI-FREE® RepleniSH® with POLYQUAD® is biocompatible with soft contact lenses, including silicone hydrogels, and is safe for sensitive eyes.

How is OPTI-FREE® RepleniSH® different from OPTI-FREE® EXPRESS®?

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OPTI-FREE® RepleniSH® MPDS is a multi-purpose disinfecting formulation that contains TearGlyde® reconditioning system. OPTI-FREE® RepleniSH® was specially designed to recondition silicone hydrogel and soft contact lenses. Both OPTI-FREE® EXPRESS® and OPTI-FREE® RepleniSH® contain POLYQUAD® and ALDOX®, disinfecting agents for compatible disinfection with soft contact lenses.

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Why does OPTI-FREE® RepleniSH® remove more lysozyme than other solutions?

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OPTI-FREE® RepleniSH® MPDS contains citrate which provides superior removal of lysozyme deposits from soft contact lenses. In addition, TearGlyde® reconditioning system has a positive effect on both surface wetting and cleaning.

Why are POLYQUAD® and ALDOX® included?

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Solutions containing the POLYQUAD® and ALDOX® system achieve a high level of disinfection activity against bacteria and fungi.^9-11 POLYQUAD® and ALDOX® also provide biocompatible disinfection with silicone hydrogel and soft contact lens materials.

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Has OPTI-FREE® RepleniSH® been tested against Acanthamoeba?

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Yes, OPTI-FREE® RepleniSH® MPDS has demonstrated activity against Acanthamoeba.¹¹

What does TearGlyde® consist of?

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The TearGlyde® system consists of Tetronic®† 1304 and CD-ED3A. TearGlyde® works synergistically with a patient's natural tears to retain moisture on silicone hydrogels and soft lenses for enhanced comfort.

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What does "reconditioning" refer to?

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While your lenses are soaking in the lens case, OPTI-FREE® RepleniSH® MPDS with TearGlyde® reconditions the lens surface by adsorbing a proprietary wetting system to the lens surface. TearGlyde® reconditioning system works with the patient's own tear components to retain moisture on the lens surface. This allows for a continuous shield of moisture between the lens and the eye, providing comfort all day by keeping the lenses moist.

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References

1. Jones L, MacDougall N, Sorbara GL. Asymptomatic corneal staining associated with the use of balafilcon silicone-hydrogel contact lenses disinfected with a polyaminopropyl biguanide-preserved care regimen. Optcom Vis Sci. 2002;79:753-761
2. Jones L, Dumbleton K, Bayer S, et.al. Clinical performance and corneal staining associated with silicone hydrogel materials used on a daily wear basis. Presentation to AAO meeting, Hawaii, May 2004.
3. Pritchard N, Young G, Coleman S, Hunt C. Subjective and objective measures of corneal staining related to multi-purpose care systems. Contact Lens & Anterior Eye 26:2003;3-9.
4. Lebow K, Schachet, J. Evaluation of corneal staining and patient preference with use of three multi-purpose solutions and two brands of soft contact lenses. Eye & Contact Lens Vol. 29, No. 4, October 2003
5. Steigemeier MJ, Cedrone R, Evans D, et.al. Clinical Performance of 'no rub' Multi-Purpose Solutions. Contact Lens Ant. Eye 2004;27:65-74.
6. Løfstrøm T, Kruse A. Multi-purpose contact lens solution-an overlooked risk factor? CLAO 2001
7. Stiegemeier M, Friederichs G, Hughes J, Larsen S, Movic W, Potter W. Clinical evaluation of a new multi-purpose disinfecting solution in symptomatic contact lens wearers. Contact Lens & Anterior Eye, May 2006.
8. Stone R., Napier L, et al. Clinical Experience with a New Multi-Purpose Disinfecting Solution. Poster presented at BCLA 2006.
9. Rosenthal, RA, Henry, CL, Buck, SL, Bell, WM, Stone, RP, Schlech, BA. Extreme testing of contact lens disinfecting products. Reprinted from Contact Lens Spectrum (July 2002).
10. Rosenthal RA, Bell WM, Schlech BA. Evaluation of a new contact lens disinfection formulation for disinfectant efficacy. Poster presented at AOA,2005.
11. Rosenthal RA, Bell WM, Henry CL. Antimicrobial Spectrum of a New Contact Lens Disinfectant. Poster presented at AAO, 2005.