Purpose:
Clinical signs and symptoms vary depending on contact
lens brand, lens care products, or a combination of the two. Studies
evaluated corneal staining and subject preference associated with three
multi-purpose solutions (MPS) and two soft contact lens brands.
Methods:
Two sites conducted the randomized, investigator-masked,
2-month crossover studies. Forty-five subjects used Regimen 1 (No Rub
OPTI-FREE® EXPRESS® MSP [Alcon, Fort Worth, TX]) and Regimen 2
(Complete* MPS [Allergan, Irvine, CA]) for 1 month each (study 1). In study
2, 44 subjects used Regimen 1 and Regimen 3 (ReNu MultiPlus* MPS
[Bausch & Lomb, Rochester, NY]). ACUVUE* 2 (Johnson & Johnson Vision
Care, Jacksonville, FL) or SofLens* 66 (Bausch & Lomb) lenses were
randomly assigned to subjects for the duration of the study. Corneal
staining was evaluated on days 0 (baseline), 7, 14, and 28 of each
month.
Results:
Corneal staining was significantly worse with Regimen 3
for both lens brands at day 28 compared with basline (P < 0.01).
Significant differences in staining were noted between Regimens 1 and
3 throughout the study, primarily with SofLens* 66 lenses (P < 0.0002). No
consistent changes in staining were noted with Regimens 1 and 2. Also,
significantly more subjects preferred the comfort of Regimen 1 (61.8%)
to that of Regimen 3 (11.8%). More subjects preferred the comfort of
Regimen 1 (57.1%) to that of Regimen 3 (10.7%) compared with their
prestudy regimen.
Conclusion:
These studies showed that chemical variations between
lens care systems and their interaction with contact lens materials
create significant clinical, physiologic, and subjective preference
differences.
Citation:
