Purpose:
Evaluate subjective comfort and satisfaction, corneal staining
and lens deposits with the latest formulations of two MPS when used
with FDA Group II and Group IV soft contact lenses according to their
current ‘no rub’ indications.
Methods:
Multi-site, 231-subject double-masked bilateral crossover
study to evaluate subjective comfort and satisfaction, corneal staining
and lens deposits with two ‘no rub’ multi-purpose solutions (MPS)
used with FDA Group II (alphafilcon A, SofLens* 66, Bausch & Lomb)
and Group IV (etafilcon A, SUREVUE*, Johnson & Johnson Vision Care)
soft contact lenses. Subjects used each of the two MPS, Regimen 1
(OPTI-FREE® EXPRESS® Multi-Purpose Disinfecting Solution No Rub™
Lasting Comfort Formula, Alcon Laboratories) and Regimen 2 (ReNu
MultiPlus* Multi-Purpose Solution, Bausch & Lomb), for 28 days.
They wore the same lens type for the duration of the study and were
evaluated on days 0, 14 and 28 of each treatment period.
Results:
Subjective ratings of comfort and satisfaction were significantly
different between regimens, with the majority of variables in favour of
Regimen 1 (P < 0.05). Corneal staining was significantly greater with the
Group II, Regimen 2 combination (P < 0.0001). Group IV lenses cared for
with Regimen 1 had significantly less residual lysozyme on Day 28
(562 ug) than lenses cared for with Regimen 2 (1145 ug; P < 0.0001).
While both products offer the convenience of a ‘no rub’ regimen,
differences in performance should be considered when recommending
these solutions to patients.
Citation:
